Cell Nuclei: Anything but Random by Caleb Colley, Ph.D.

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Cell Nuclei: Anything but Random

by	Caleb Colley, Ph.D.

At the heart of biological evolutionary theory is randomness. Evolutionists claim that the human body is the result of random mutations prompted by natural selection. According to the University of California at Berkeley, “The mechanisms of evolution—like natural selection and genetic drift—work with the random variation generated by mutation” (“Mutations...,” n.d.).

However essential a pillar of evolution the random may be, it is antithetical to what we actually observe in nature, even in the basic unit of all living matter—the cell (Aw, 1982, p. 127). New research suggests that the nucleus of a mammal cell is made up of component parts arranged in a pattern which can be predicted statistically (“Scientists Prove...,” 2006). Systems biologists worked with mathematicians to identify, for the first time, “spatial relationships” governing the distribution of an important control protein in the nucleus, in relation to other components within the nuclei of mammal cells (“Scientists Prove...,” 2006).

The study, published in PLoS Computational Biology, reports that, “[i]t is becoming increasingly clear that nuclear macromolecules and macromolecular complexes are compartmentalized through binding interaction into an apparent three-dimensionally ordered structure” (McManus, et al., 2006). The widespread protein CBP acts on certain genes within the cell nucleus, causing them to make specific proteins at different times throughout the life of the cell (“Scientists Prove...”). The scientists developed a probability map for the nucleus and determined that CBP pockets are more likely to be located closest to the gene regions with which they are known to modify (“Scientists Prove...”).

Also, scientists at Purdue University and Lawrence Berkeley National Laboratory have created a technique that automatically locates and maps proteins involved in regulated cell behavior (“New Cell Imaging...,” 2006, p. 46). This allows the cancer researcher, for example, to verify the distinction between multiplying cells that are harmless and those that are malignant (4:46).

Perhaps these new advances constitute substantial progress in scientific examination of cellular life, but they certainly are not the first observations of incredibly sophisticated organization in the cell. Indeed, to observe cells at all is to observe strict organization in the human body itself, for the body is composed in a hierarchy of organs, tissues, and cells. And while it may be very useful to try to put things such as DNA and proteins in the perspective of a cell, “the amazing beauty and complexity of a cell is not always easy to grasp because of the very small sizes involved.... Cells have typical radius [sic] of 10 to 30 microns” (one micron equals a millionth of a meter; Baldi, 2001, p., 22).

Cellular divisions of organic matter were identified and given the name “cells” as long ago as 1663 by the English scientist Robert Hooke (Pfeiffer, 1964, p. 9). Although some 17th-century scientists realized how ridiculous it would be to suggest that something as obviously structured as a human body was composed of randomly assembled components, they did not understand fully the complexity of the cell. Ernst Haeckel, the famed proponent of embryonic recapitulation, contended even in 1877: “the cell consists of matter called protoplasm, composed chiefly of carbon, with an admixture of hydrogen, nitrogen and sulphur. These component parts, properly united, produce the soul and body of the animated world, and suitably nursed become man” (as quoted in Eiseley, 1961, p. 346).

By the mid-20th century, technology had opened the eyes of scientists to a deepened examination of the cell’s inner workings:

The microscopic blob of jelly called the cell is a remarkable entity. The most remarkable thing about it is the very fact that it is alive—not with a murky primordial glow, but as fully and vibrantly alive as a tiger or an oak tree. In a remarkable miniaturization of life’s functions, the cell moves, grows, reacts, protects itself and even reproduces. To sustain this varied existence, it utilizes a tightly organized system of parts that is much like a tiny industrial complex. It has a central control point, power plants, internal communications, construction and manufacturing elements (Pfeiffer, 1964, p. 16).

Reports of cellular organization do not surprise creationists, who understand that each cell is built according to fundamental design principles. Considering that even the most minute cell is capable of the five activities of life (metabolism, growth, reproduction, responsiveness, and autonomous movement), it only makes sense that the “brain” of the cell—the nucleus—is organized in a recognizable pattern.

In their cytology textbook, Cell Biology, Roberts, Nowinski, and Saez wrote: “[I]t has been demonstrated that beyond the organization visible with the light microscope are a number of more elementary structures at the macromolecular level that constitute the ‘ultrastructure’ of the cell. We find ourselves in the era of molecular biology...” (1970, p. 3). That was 1970, a few years after the advent of the electron microscope, which made it possible to study intracellular structures and their interrelationship. Scientists consistently have found that different parts of the cell relate to each other. Baldi wrote that the cell structure could be illustrated by a football stadium:

In the stadium, proteins come in many shapes and sizes, but typically have the dimensions of a tennis ball.... [P]roteins are extremely busy in the stadium as they continually bind and interact with each other.... Somehow proteins must find their way to the region of their activity: the football field (nucleus), the rest of the stadium (cytoplasm), the wall around the stadium (membrane), or even the external world in the case of secreted proteins. They are what keeps the stadium functioning, by generating energy, removing waste, exchanging food and other signals with the external world, producing other tennis balls, fighting enemies, and so on.... From time to time, proteins take care of the very complex events by which an entire stadium is precisely duplicated into two stadiums... (2001, pp. 23-24).

Evolutionists believe that the first living cell appeared 3.5 billion years ago and gradually increased in sophistication and organization (Baldi, 2001, p. 25). How and why did it appear? Is it reasonable to assume that the original nucleus, in all its complexity and organization, simply came together for no apparent reason, and then summoned the remaining cellular parts to join in the fight for existence? Is the origin of the cell explicable on strictly natural bases?

Such is illogical for several reasons, not the least of which is the existence of Deoxyribonucleic acid (DNA) and its vital role in the nucleus and in the life of the cell. The DNA is a supermodule that carries the coded information for the replication of the cell. It stores coded information in a chemical format and then uses a biologic agent (RNA) to decode and activate it. As Darrel Kautz has stated: “Human technology has not yet advanced to the point of storing information chemically as it is in the DNA module” (1988, p. 45, emp. in orig.; see also Jackson, 1993, pp. 11-12). The DNA regulates life and directs its synthesis (see Thompson, 2003, pp. 78-86).

The DNA, all within the nucleus, stores a tremendous amount of information. If transcribed into English, the DNA in the human genome would fill a 300-volume set of encyclopedias of approximately 2,000 pages each (Baldi, 2001, p. 21). As Jackson concluded, “a programmed message is not self-explanatory in terms of its origin. One must assume that someone wrote the initial program. A program does not write itself! Similarly, it is obvious that someone has programmed the data in the DNA” (1993, p. 11). The cell, with its complex nucleus, could not have developed accidentally.

Furthermore, consider cellular reproduction and the important role of DNA in the process. In mitosis, cell division is “a mathematically precise doubling of the chromosomes and their genes. The two chromosome sets so produced then become separated and become part of two newly formed nuclei” so that “the net result of cell division is the formation of two cells that match each other and the parent cell precisely in their gene contents and that contain approximately equal amounts and types of all other components” (Weisz and Keogh, 1977, pp. 322,325).

We demonstrated that the cell could not have developed accidentally. For the sake of argument, however, suppose that a single cell did “appear.” What then? Evolutionists are burdened to explain how and why the first living cell, 3.5 billion years ago, would have perceived a need to divide itself and reproduce. Evolution quickly becomes a logistical conundrum.

CONCLUSION

For purposes of research and experimentation, scientists depend on regular patterns at the cellular level. Such is possible only because cells exhibit precise organization. To believe evolution is to believe that the random gave rise to the organized by accident. Such a position is increasingly recognized as irrational in the presence of cellular organization. Sir Fred Hoyle, a prominent British scientist, has argued that the chance of higher life-forms emerging accidentally is comparable to the chance that a Boeing 747 jet could be assembled by a tornado sweeping through a junkyard (1981, 294:105). Thankfully, we have a more sensible explanation: “It is He Who has made us” (Psalm 100:3). God designed the eukaryotic human cell and its nucleus!

REFERENCES

Aw, S.E. (1982), Chemical Evolution: An Examination of Current Ideas (San Diego, CA: Master).

Baldi, Pierre (2001), The Shattered Self (Cambridge, MA: MIT).

Eiseley, Loren C. (1961), Darwin’s Century: Evolution and the Men Who Discovered It (Garden City, NY: Anchor).

Hoyle, Fred (1981), “Hoyle on Evolution,” Nature, 294:105, November 12.

Jackson, Wayne (1993), The Human Body—Accident or Design? (Stockton, CA: Courier).

Kautz, Darrel (1988), The Origin of Living Things (Milwaukee, WI: Darrel Kautz).

McManus, Kirk J., et al. “The Transcriptional Regulator CBP Has Defined Spatial Associations with Interphase Nuclei” (2006), PLoS Computational Biology, [On-line], URL: http://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371/ journal.pcbi.0020139.

“Mutations are Random” (no date), University of California at Berkeley, [On-line], URL: http://evolution.berkeley.edu/evosite/evo101/IIIC1aRandom.shtml.

“New Cell Imaging Method Identifies Aggressive Cancer Cells Early” (2006), Bioscience Technology, 4:46-47, April.

Pfeiffer, John (1964), The Cell (New York: Time).

Roberts, E.D.P., Wiktor W. Nowinski, and Francisco A. Saez (1970), Cell Biology (Philadelphia, PA: W.B. Saunders).

“Scientists Prove that Parts of Cell Nuclei are Not Arranged at Random” (2006), Imperial College London, [On-line], URL: http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/ news_20-10-2006-8-43-24.

Thompson, Bert (2003), The Case for the Existence of God (Montgomery, AL: Apologetics Press).

Weisz, Paul B. and Richard N. Keogh (1977), Elements of Biology (New York: McGraw-Hill).